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M94A2945.TXT
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1994-10-25
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Document 2945
DOCN M94A2945
TI Liver disease in patients with AIDS.
DT 9412
AU Silva MA; Tannuri AA; Lobo AL; Costa RS; Mello CE; Lima MB; Oliveira CA;
University of Rio de Janeiro, Brazil.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):189 (abstract no. PB0183). Unique
Identifier : AIDSLINE ICA10/94369630
AB OBJECTIVE: The evaluation of clinical, biochemical, serological and
morphological data of liver involvement in high risk groups with AIDS
was the aim of this work. Our purpose was to determine the spectrum of
liver disease in AIDS and the clinic morphological correlation in order
to ascertais if any clinical or phatological feature was characteristic
of AIDS. MATERIAL: We have evaluated 215 patients with AIDS, being 30
hemophiliacs (19A and 2B) severely affected and 185 homosexual men.
METHODS: We studied hepatitis B virus (HBV) serum markers by commercial
RIA kits for the detection of HBsAg, Anti-HBs, Anti-HBc, HBeAg and
Anti-HBe. Liver function tests including aminotransferases, total
bilirubin, alkaline fosfatase were performed. Mostly of the liver
biopsies were obtained percutaneously, but some samples were obtained
from necropsy material. RESULTS: The great majority of the patients were
anicteric. More than 80% of them were Anti-HBs and Anti-HBc(+). Serum
aminotransferases levels were mildly elevated (less than twice the upper
limit of the normal range) 10 the majority of the patients. Liver
tuberculosis, chronic active hepatitis, sinusoidal dilatation,
hiperplasy of Kupffer cells, cirrhosis were the most frequent findings
in this study. We also found the presence of hepatocellular carcinoma,
cryptococcosis, histoplasmosis, amebiasis and schistosomiasis.
CONCLUSIONS: a) The clinical and biochemical alterations of the liver in
AIDS patients were subclinical and not very characteristic; b)
Morphologicaly there was conspicuous predominance of chronic liver
disease, opportunistic liver infecciousin special due to Mycobacterium.
DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS/DIAGNOSIS/ PATHOLOGY
AIDS-Related Opportunistic Infections/DIAGNOSIS/PATHOLOGY Biopsy
Hemophilia/COMPLICATIONS/PATHOLOGY Hepatitis
B/COMPLICATIONS/DIAGNOSIS/PATHOLOGY Human Liver/PATHOLOGY Liver
Cirrhosis/COMPLICATIONS/DIAGNOSIS/PATHOLOGY Liver
Diseases/*COMPLICATIONS/DIAGNOSIS/PATHOLOGY Liver Function Tests
Substance Abuse, Intravenous/COMPLICATIONS/PATHOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).